Richness of human gut microbiome correlates with metabolic markers
Emmanuelle Le Chatelier
(1)
,
Trine Nielsen
(2)
,
Junjie Qin
(3)
,
Edi Prifti
(1)
,
Falk Hildebrand
(4, 5)
,
Gwen Falony
(4, 5)
,
Mathieu Almeida
(1)
,
Manimozhiyan Arumugam
(2, 3)
,
Jean-Michel Batto
(1)
,
Sean Kennedy
(1)
,
Pierre Léonard
(1)
,
Junhua Li
(3, 6)
,
Kristoffer Burgdorf
(2)
,
Niels Grarup
(2)
,
Torben Jørgensen
(7, 8, 9)
,
Ivan Brandslund
(10, 11)
,
Henrik Bjørn Nielsen
(12)
,
Agnieszka S. Juncker
(12)
,
Marcelo Bertalan
(12)
,
Florence Levenez
(1)
,
Nicolas Pons
(1)
,
Simon Rasmussen
(12)
,
Shinichi Sunagawa
,
Julien Tap
(1)
,
Sebastian Tims
(13)
,
Erwin G. Zoetendal
(13)
,
Søren Brunak
(12)
,
Karine Clément
(14, 15, 16)
,
Joel Dore
(17, 1)
,
Michiel Kleerebezem
(13)
,
Karsten Kristiansen
(18)
,
Pierre Renault
(17)
,
Thomas Sicheritz-Ponten
(12)
,
Willem M. de Vos
(13, 19)
,
Jean-Daniel Zucker
(14, 15, 20)
,
Jeroen Raes
(4, 5)
,
Torben Hansen
(2, 21)
,
Peer Bork
,
Jun Wang
(3, 2, 22, 23)
,
Stanislav Ehrlich
(1)
,
Oluf Pedersen
(2, 24, 25)
,
Eric Guédon
(17)
,
Christine Delorme
(17)
,
Séverine Layec
(17)
,
Ghalia Kaci
(17)
,
Maarten van de Guchte
(17)
,
Gaetana Vandemeulebrouck
(17)
,
Alexandre Jamet
(17)
,
Rozenn Dervyn
(17)
,
Nicolas Sanchez
(17)
,
Emmanuelle Maguin
(26)
,
Florence Haimet
(1)
,
Yohanan Winogradsky
(17)
,
Antonietta Cultrone
(17)
,
Marion Leclerc
(17)
,
Catherine Juste
(17)
,
Herve Blottiere
(17)
1
MetaGenoPolis
2 CBMR - Novo Nordisk Foundation Center for Basic Metabolic Research
3 BGI - Beijing Genomics Institute [Shenzhen]
4 Department of Structural Biology
5 Department of Bioscience Engineering
6 School of Bioscience and Biotechnology
7 RCPH - Research Centre for Prevention and Health
8 Faculty of Health and Medical Sciences
9 Faculty of Medicine, Institute of Public Health
10 Department of Clinical Biochemistry
11 Institute of Regional Health Research
12 Center for Biological Sequence Analysis & Novo Nordisk Foundation Center for Biosustainability
13 Laboratory of Microbiology
14 U872 Centre de Recherche des Cordeliers, Nutriomique, Équipe 7
15 UPMC - Université Pierre et Marie Curie - Paris 6
16 CRNH-RA - Centre de Recherche en Nutrition Humaine Rhône-Alpes
17 MICALIS - MICrobiologie de l'ALImentation au Service de la Santé
18 Department of Biology [Copenhagen]
19 Department of Bacteriology and Immunology [Helsinki]
20 UMMISCO - Unité de modélisation mathématique et informatique des systèmes complexes [Bondy]
21 Faculty of Health Sciences
22 King Abdulaziz University
23 Center for Sequencing
24 Hagedorn Research Institute
25 Faculty of Health
26 MICA - Département Microbiologie et Chaîne Alimentaire
2 CBMR - Novo Nordisk Foundation Center for Basic Metabolic Research
3 BGI - Beijing Genomics Institute [Shenzhen]
4 Department of Structural Biology
5 Department of Bioscience Engineering
6 School of Bioscience and Biotechnology
7 RCPH - Research Centre for Prevention and Health
8 Faculty of Health and Medical Sciences
9 Faculty of Medicine, Institute of Public Health
10 Department of Clinical Biochemistry
11 Institute of Regional Health Research
12 Center for Biological Sequence Analysis & Novo Nordisk Foundation Center for Biosustainability
13 Laboratory of Microbiology
14 U872 Centre de Recherche des Cordeliers, Nutriomique, Équipe 7
15 UPMC - Université Pierre et Marie Curie - Paris 6
16 CRNH-RA - Centre de Recherche en Nutrition Humaine Rhône-Alpes
17 MICALIS - MICrobiologie de l'ALImentation au Service de la Santé
18 Department of Biology [Copenhagen]
19 Department of Bacteriology and Immunology [Helsinki]
20 UMMISCO - Unité de modélisation mathématique et informatique des systèmes complexes [Bondy]
21 Faculty of Health Sciences
22 King Abdulaziz University
23 Center for Sequencing
24 Hagedorn Research Institute
25 Faculty of Health
26 MICA - Département Microbiologie et Chaîne Alimentaire
Emmanuelle Le Chatelier
- Fonction : Auteur
- PersonId : 737756
- IdHAL : emmanuelle-le-chatelier
- ORCID : 0000-0002-2724-0536
Trine Nielsen
- Fonction : Auteur
- PersonId : 770024
- ORCID : 0000-0002-2066-7895
Edi Prifti
- Fonction : Auteur
- PersonId : 1151183
- IdHAL : edi-prifti
- ORCID : 0000-0001-8861-1305
- IdRef : 155572822
Manimozhiyan Arumugam
- Fonction : Auteur
- PersonId : 770023
- ORCID : 0000-0002-0886-9101
Junhua Li
- Fonction : Auteur
- PersonId : 770145
- ORCID : 0000-0001-6784-1873
Shinichi Sunagawa
- Fonction : Auteur
Julien Tap
- Fonction : Auteur
- PersonId : 1172956
- IdHAL : julien-tap
- ORCID : 0000-0001-8998-5413
Karine Clément
- Fonction : Auteur
- PersonId : 756892
- ORCID : 0000-0003-4619-6785
- IdRef : 07341512X
Karsten Kristiansen
- Fonction : Auteur
- PersonId : 757952
- ORCID : 0000-0002-6024-0917
Jean-Daniel Zucker
- Fonction : Auteur
- PersonId : 9387
- IdHAL : jean-daniel-zucker
- ORCID : 0000-0002-5597-7922
- IdRef : 070019495
Torben Hansen
- Fonction : Auteur
- PersonId : 758676
- ORCID : 0000-0001-8748-3831
Peer Bork
- Fonction : Auteur
Jun Wang
- Fonction : Auteur
- PersonId : 881572
Oluf Pedersen
- Fonction : Auteur
- PersonId : 1070332
Eric Guédon
- Fonction : Auteur
- PersonId : 743950
- IdHAL : eguedon35
- ORCID : 0000-0002-0901-4447
- IdRef : 140101888
Christine Delorme
- Fonction : Auteur
- PersonId : 736589
- IdHAL : christine-delorme
- ORCID : 0000-0002-5208-7238
- IdRef : 124303129
Séverine Layec
- Fonction : Auteur
- PersonId : 754110
- IdHAL : severine-layec
- ORCID : 0000-0001-5053-8712
Maarten van de Guchte
- Fonction : Auteur
- PersonId : 735862
- IdHAL : maarten-van-de-guchte
- ORCID : 0000-0002-5980-4631
Gaetana Vandemeulebrouck
- Fonction : Auteur
- PersonId : 969463
Alexandre Jamet
- Fonction : Auteur
- PersonId : 737690
- IdHAL : alexandre-jamet
- IdRef : 253129699
Emmanuelle Maguin
- Fonction : Auteur
- PersonId : 751613
- IdHAL : e-maguin
- ORCID : 0000-0001-5452-3382
- IdRef : 032881487
Marion Leclerc
- Fonction : Auteur
- PersonId : 748825
- IdHAL : marion-leclerc
- ORCID : 0000-0001-8684-2847
- IdRef : 142653721
Herve Blottiere
- Fonction : Auteur
- PersonId : 747227
- IdHAL : herve-blottiere
- ORCID : 0000-0002-8390-0607
- IdRef : 076955648
Résumé
We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we report the human gut microbial composition in a population sample of 123 non-obese and 169 obese Danish individuals. We find two groups of individuals that differ by the number of gut microbial genes and thus gut bacterial richness. They contain known and previously unknown bacterial species at different proportions; individuals with a low bacterial richness (23% of the population) are characterized by more marked overall adiposity, insulin resistance and dyslipidaemia and a more pronounced inflammatory phenotype when compared with high bacterial richness individuals. The obese individuals among the lower bacterial richness group also gain more weight over time. Only a few bacterial species are sufficient to distinguish between individuals with high and low bacterial richness, and even between lean and obese participants. Our classifications based on variation in the gut microbiome identify subsets of individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities.
Format du dépôt | Fichier |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Richness of human gut microbiome correlates with metabolic markers
|
Résumé |
en
We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we report the human gut microbial composition in a population sample of 123 non-obese and 169 obese Danish individuals. We find two groups of individuals that differ by the number of gut microbial genes and thus gut bacterial richness. They contain known and previously unknown bacterial species at different proportions; individuals with a low bacterial richness (23% of the population) are characterized by more marked overall adiposity, insulin resistance and dyslipidaemia and a more pronounced inflammatory phenotype when compared with high bacterial richness individuals. The obese individuals among the lower bacterial richness group also gain more weight over time. Only a few bacterial species are sufficient to distinguish between individuals with high and low bacterial richness, and even between lean and obese participants. Our classifications based on variation in the gut microbiome identify subsets of individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities.
|
Auteur(s) |
Emmanuelle Le Chatelier
1
, Trine Nielsen
2
, Junjie Qin
3
, Edi Prifti
1
, Falk Hildebrand
4, 5
, Gwen Falony
4, 5
, Mathieu Almeida
1
, Manimozhiyan Arumugam
2, 3
, Jean-Michel Batto
1
, Sean Kennedy
1
, Pierre Léonard
1
, Junhua Li
3, 6
, Kristoffer Burgdorf
2
, Niels Grarup
2
, Torben Jørgensen
7, 8, 9
, Ivan Brandslund
10, 11
, Henrik Bjørn Nielsen
12
, Agnieszka S. Juncker
12
, Marcelo Bertalan
12
, Florence Levenez
1
, Nicolas Pons
1
, Simon Rasmussen
12
, Shinichi Sunagawa
, Julien Tap
1
, Sebastian Tims
13
, Erwin G. Zoetendal
13
, Søren Brunak
12
, Karine Clément
14, 15, 16
, Joel Dore
17, 1
, Michiel Kleerebezem
13
, Karsten Kristiansen
18
, Pierre Renault
17
, Thomas Sicheritz-Ponten
12
, Willem M. de Vos
13, 19
, Jean-Daniel Zucker
14, 15, 20
, Jeroen Raes
4, 5
, Torben Hansen
2, 21
, Peer Bork
, Jun Wang
3, 2, 22, 23
, Stanislav Ehrlich
1
, Oluf Pedersen
2, 24, 25
, Eric Guédon
17
, Christine Delorme
17
, Séverine Layec
17
, Ghalia Kaci
17
, Maarten van de Guchte
17
, Gaetana Vandemeulebrouck
17
, Alexandre Jamet
17
, Rozenn Dervyn
17
, Nicolas Sanchez
17
, Emmanuelle Maguin
26
, Florence Haimet
1
, Yohanan Winogradsky
17
, Antonietta Cultrone
17
, Marion Leclerc
17
, Catherine Juste
17
, Herve Blottiere
17
1
MetaGenoPolis
( 452633 )
- Centre de recherche - 78352 Jouy-en-Josas
- France
2
CBMR -
Novo Nordisk Foundation Center for Basic Metabolic Research
( 226376 )
- Blegdamsvej 3B, Building 7 (Maersk Tower)
DK-2200 Copenhagen N
- Danemark
3
BGI -
Beijing Genomics Institute [Shenzhen]
( 228027 )
- 11F, Bei Shan Industrial Zone Yantian District Shenzhen 518083
- Chine
4
Department of Structural Biology
( 428302 )
- Belgique
5
Department of Bioscience Engineering
( 428303 )
- Belgique
6
School of Bioscience and Biotechnology
( 428304 )
- Chine
7
RCPH -
Research Centre for Prevention and Health
( 154782 )
- Danemark
8
Faculty of Health and Medical Sciences
( 574694 )
- Blegdamsvej 3B
DK-2200 Copenhagen N
Denmark
- Danemark
9
Faculty of Medicine, Institute of Public Health
( 428306 )
- Danemark
10
Department of Clinical Biochemistry
( 428307 )
- Danemark
11
Institute of Regional Health Research
( 428308 )
- Danemark
12
Center for Biological Sequence Analysis & Novo Nordisk Foundation Center for Biosustainability
( 428309 )
- Danemark
13
Laboratory of Microbiology
( 428310 )
- Pays-Bas
14
U872 Centre de Recherche des Cordeliers, Nutriomique, Équipe 7
( 428311 )
- France
15
UPMC -
Université Pierre et Marie Curie - Paris 6
( 93591 )
- 4 place Jussieu - 75005 Paris
- France
16
CRNH-RA -
Centre de Recherche en Nutrition Humaine Rhône-Alpes
( 1002336 )
- 165 chemin du Grand Revoyet, 69310 PIERRE-BENITE
- France
17
MICALIS -
MICrobiologie de l'ALImentation au Service de la Santé
( 132919 )
- F-78350 JOUY-EN-JOSAS
- France
18
Department of Biology [Copenhagen]
( 522127 )
- Copenhagen Biocenter, Ole Maaløes Vej 5, DK-2200 Copenhagen N
- Danemark
19
Department of Bacteriology and Immunology [Helsinki]
( 460137 )
- P.O. Box 21, FI 00014. Helsinki, Finland
- Finlande
20
UMMISCO -
Unité de modélisation mathématique et informatique des systèmes complexes [Bondy]
( 100405 )
- IRD France Nord - 32 avenue Henri Varagnat - 93143 Bondy cedex
- France
21
Faculty of Health Sciences
( 193609 )
- Odense
- Danemark
22
King Abdulaziz University
( 422761 )
- Djeddah 21589
- Arabie saoudite
23
Center for Sequencing
( 428314 )
- Danemark
24
Hagedorn Research Institute
( 327738 )
-
- France
25
Faculty of Health
( 428316 )
- Danemark
26
MICA -
Département Microbiologie et Chaîne Alimentaire
( 133368 )
- JOUY-EN-JOSAS
- France
|
URL éditeur |
http://www.nature.com/nature/index.html
|
Public visé |
Scientifique
|
Sous-type de document pour les Articles |
Research article
|
Version du document |
version éditeur
|
Page/Identifiant |
541-546
|
Langue du document |
Anglais
|
Nom de la revue |
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Audience |
Non spécifiée
|
Date de publication |
2013
|
Volume |
500
|
Numéro |
7464
|
Indexation contrôlée |
|
Voir aussi |
|
Financement |
|
Domaine(s) |
|
Projet(s) ANR |
|
Mots-clés |
en
weight loss, reared apart, wide association, disease, adiposity, inflammation, body mass index, diet induced obesity, insulin resistance, twins
|
DOI | 10.1038/nature12506 |
ProdINRA | 209498 |
UT key WOS | 000323625900026 |
Origine :
Fichiers produits par l'(les) auteur(s)
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