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1. Hz, 16-7.42 (m, 20H); 13 C NMR (75 MHz, CD 3 OD) ? ppm 59, dd, J ) 2.6, 10.2 Hz Hz, 1H), 4.49-4.69 (m, 5H), 4.75 (d, J ) 12.0 Hz, 1H), 4.84 (d, J ) 10.6 Hz, 1H); N, 2.68. (2R,3R,4R,5R)-2-(Hydroxymethyl)piperidine-1,3 To a stirred solution of hydroxylamine 12 (105 mg, 0.19 mmol) in CH 2 Cl 2, pp.7992-7995

. Meoh, mL) was added, and then mixture was concentrated under vacuum This operation was repeated six times. The crude product was dissolved in H 2 O (4 mL) and stirred with DOWEX 1X8 (OH form ) until pH 6. After filtration, the filtrate was concentrated under vacuum to give 15 (31 mg, 91%) as a pale oil, pp.20-47

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