Early estimates of 2016/17 seasonal influenza vaccine effectiveness in primary care in France

Cécile Souty 1 Ana-Maria Vilcu 1 Lisandru Capai 1, 2 Sylvie van der Werf 3, 4 Martine Valette 5 Thierry Blanchon 1 Bruno Lina 5, 6 Sylvie Behillil 3, 4 Thomas Hanslik 1, 7, 8 Alessandra Falchi 2
1 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
2 EA Bioscope Corse Méditerranée : Dynamique des infections virales en milieu insulaire
UPP - Université Pascal Paoli, INSERM - Institut National de la Santé et de la Recherche Médicale : EA 7310
3 Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses
4 CNR - Centre National de Référence des virus influenzae (Grippe)-Génétique moléculaire des virus à ARN
5 Virpath - Virpath-Grippe, de l'émergence au contrôle -- Virpath-Influenza, from emergence to control
CIRI - Centre International de Recherche en Infectiologie - UMR
6 CIRI - Centre International de Recherche en Infectiologie - UMR
7 Service de Médecine Interne
8 UFR des sciences de la santé Simone Veil
Abstract : Background: The ongoing 2016/17 influenza epidemic in France is characterized by the circulation of A(H3N2) viruses, known to cause more severe illness among at risk populations.Objectives: The purpose of our study was to provide early influenza vaccine effectiveness (IVE) estimates for the ongoing influenza epidemic in France and compare these estimates over the six post-pandemic IVE.Study design: We used clinical and virological data collected in primary care by the French Sentinelles network. IVE in preventing influenza infection was estimated by the test-negative design method. The screening method was used to estimate IVE in preventing medically-attended influenza-like illness among target groups (<65 year with chronic diseases and ≥65 years) since 2010/11 influenza epidemic.Results: Early IVE estimates in primary care against influenza A(H3N2) were 48% (95% confidence interval (CI): 22 to 66) overall and 39% (95% CI: -17 to 69) among elderly (aged 65 and older). In comparison to the last six epidemics, 2016/17 early IVE in preventing influenza-like illness among target groups showed VE estimates higher to those reported during the 2011/12 and 2014/15 epidemics.Conclusions: The moderate 2016/17 IVE estimates were higher than those estimated during influenza A(H3N2) epidemics with vaccine mismatch.
Keywords : primary care influenza influenza-like illness vaccine effectiveness
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AFRIQ | UNIV-CORSE | IPLESP | UPMC | UVSQ | UNIV-PARIS-SACLAY | PASTEUR | UNIV-LYON1 | CIRI | VIRPATH-CIRI | SORBONNE-UNIVERSITE | UNIV-PARIS7 | USPC | SU-MEDECINE | ENS-LYON

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Cécile Souty, Ana-Maria Vilcu, Lisandru Capai, Sylvie van der Werf, Martine Valette, et al.. Early estimates of 2016/17 seasonal influenza vaccine effectiveness in primary care in France. Journal of Clinical Virology, Elsevier, 2017, 95, pp.1 - 4. ⟨10.1016/j.jcv.2017.08.002⟩. ⟨hal-01582085⟩

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