Early estimates of 2016/17 seasonal influenza vaccine effectiveness in primary care in France

Cécile Souty; Ana-Maria Vilcu; Lisandru Capai; Sylvie van der Werf; Martine Valette; Thierry Blanchon; Bruno Lina; Sylvie Behillil; Thomas Hanslik; Alessandra Falchi

Early estimates of 2016/17 seasonal influenza vaccine effectiveness in primary care in France

Cécile Souty ¹ Ana-Maria Vilcu ¹ Lisandru Capai ^{1, 2} Sylvie van der Werf ^{3, 4} Martine Valette ⁵ Thierry Blanchon ¹ Bruno Lina ^{5, 6} Sylvie Behillil ^{3, 4} Thomas Hanslik ^{1, 7, 8} Alessandra Falchi ²

1 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique

2 EA Bioscope Corse Méditerranée : Dynamique des infections virales en milieu insulaire

UPP - Université Pascal Paoli, INSERM - Institut National de la Santé et de la Recherche Médicale : EA 7310

3 Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses

4 CNR - Centre National de Référence des virus influenzae (Grippe)-Génétique moléculaire des virus à ARN

5 Virpath - Virpath-Grippe, de l'émergence au contrôle -- Virpath-Influenza, from emergence to control

CIRI - Centre International de Recherche en Infectiologie - UMR

6 CIRI - Centre International de Recherche en Infectiologie - UMR

7 Service de Médecine Interne

8 UFR des sciences de la santé Simone Veil

Abstract : Background: The ongoing 2016/17 influenza epidemic in France is characterized by the circulation of A(H3N2) viruses, known to cause more severe illness among at risk populations.Objectives: The purpose of our study was to provide early influenza vaccine effectiveness (IVE) estimates for the ongoing influenza epidemic in France and compare these estimates over the six post-pandemic IVE.Study design: We used clinical and virological data collected in primary care by the French Sentinelles network. IVE in preventing influenza infection was estimated by the test-negative design method. The screening method was used to estimate IVE in preventing medically-attended influenza-like illness among target groups (<65 year with chronic diseases and ≥65 years) since 2010/11 influenza epidemic.Results: Early IVE estimates in primary care against influenza A(H3N2) were 48% (95% confidence interval (CI): 22 to 66) overall and 39% (95% CI: -17 to 69) among elderly (aged 65 and older). In comparison to the last six epidemics, 2016/17 early IVE in preventing influenza-like illness among target groups showed VE estimates higher to those reported during the 2011/12 and 2014/15 epidemics.Conclusions: The moderate 2016/17 IVE estimates were higher than those estimated during influenza A(H3N2) epidemics with vaccine mismatch.

Keywords : primary care influenza influenza-like illness vaccine effectiveness

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Journal articles

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Life Sciences [q-bio]

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Submitted on : Tuesday, September 5, 2017 - 3:16:45 PM
Last modification on : Wednesday, April 3, 2019 - 1:31:26 AM

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