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Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA

Abstract : The advancement of multidisciplinary research fields dealing with ionising radiation induced biological damage - radiobiology, radiation physics, radiation protection and, in particular, medical physics - requires a clear mechanistic understanding of how cellular damage is induced by ionising radiation. Monte Carlo (MC) simulations provide a promising approach for the mechanistic simulation of radiation transport and radiation chemistry, towards the in silico simulation of early biological damage. We have recently developed a fully integrated MC simulation that calculates early single strand breaks (SSBs) and double strand breaks (DSBs) in a fractal chromatin based human cell nucleus model. The results of this simulation are almost equivalent to past MC simulations when considering direct/indirect strand break fraction, DSB yields and fragment distribution. The simulation results agree with experimental data on DSB yields within 13.6% on average and fragment distributions agree within an average of 34.8%.
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Submitted on : Monday, October 25, 2021 - 9:42:27 AM
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Dousatsu Sakata, Nathanael Lampe, Mathieu Karamitros, Ioanna Kyriakou, Oleg Belov, et al.. Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA. Phys.Medica, 2019, 62, pp.152-157. ⟨10.1016/j.ejmp.2019.04.010⟩. ⟨hal-02166564⟩

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